A consensus is building that air pollution can cause neurological diseases similar to Alzheimer’s disease and Parkinson’s disease; however, how fine, sooty particles trigger issues within the brain is still an unanswered question. Now a group of Penn State researchers, using mice, have found a doable way, but additional research is still needed.
The researchers checked out how cerebrospinal fluid, the liquid that flows around the mind and spinal cord, flows out via the nose, and what happens when the flow of fluid is stopped.
The query, nevertheless, is how does the cerebrospinal fluid or CSF leave the enclosed area of the brain and spinal column, and where does it go? Research into old scientific papers indicated that some scientists had speculated that one exits pathway was via the nose.
Further research into old scientific papers confirmed that not only had others prompt that the cerebrospinal fluid left by way of the nose, however that there was a connection to the sense of smell. The researchers additionally discovered that there’s a long-held connection between lack of odor and the early beginnings of such neurological diseases as Alzheimer’s disease and Parkinson’s disease.
Utilizing chemical ablation, the researchers destroyed the olfactory sensory nerves that come by way of the mouse’s hard palate. Destruction of those nerves causes a lack of the sense of smell, but besides, brought on the flow of cerebrospinal fluid to stop.
As a result of the flow of fluid from the nose stopped, the researchers checked to see if the strain across the brain and within the spinal cord increased.
The researchers believe that another pathway might enhance its flow or CSF to compensate for what would usually exit through the nose. These different pathways may embody these across the brain that drains into the lymphatic system.
One other risk is that the production of CSF decreases in response to stoppage of CSF flow through the nose.
Each the consequences of air pollution and the results of reduced CSF turnover would possibly clarify the origin of some of these diseases.