In some people, marijuana causes a rewarding high. For others, it produces severe psychiatric side effects.
Whether or not an individual enjoys the expertise or adverse effects from cannabis might be determined by which area of the brain it is performing upon, Western researchers have decided.
The psychological results of marijuana can differ between people: some expertise gratifying consequences which can result in dependence on the drug, whereas others could experience paranoia, cognitive issues, or an elevated danger of growing schizophrenia.
“Until now, it was unknown which particular areas of the mind were responsible for these extremely divergent effects of marijuana,” mentioned Steven Laviolette Ph.D., Professor at Western’s Schulich School of Medicine & Dentistry.
“Translational rodent analysis carried out in our lab has recognized extremely particular target areas within the mind that appear to independently control the rewarding, addictive properties of marijuana versus the negative psychiatric side-effects related to its use.”
The research, led by Laviolette and postdoctoral fellow, Christopher Norris, Ph.D., is newly revealed in Scientific Reports and reveals crucial new insights into how marijuana can produce such extremely various psychological results in different people.
By THC’s effect on a rat brain, the researchers confirmed that THC, the principal psychoactive compound in marijuana, can produce beneficial results within the front-most a part of a region of the brain referred to as the nucleus accumbens.
The examine confirmed that THC on this brain area not solely produced highly rewarding results in and of itself, it amplified the addictive properties of opioid medication like morphine and elevated reward-associated exercise patterns within the neurons.
In contrast, THC within the posterior area of the nucleus accumbens area produced highly adverse effects.
These included other schizophrenia-related cognitive and emotional symptoms and patterns of neuron activity, just like those found in people with schizophrenia.